Structural Changes of Rat Mitral Valve Chordae Tendineae During Postnatal Development
|
Michael G. Dickinson, Ivan Vesely Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands, Department of Cardiothoracic Surgery, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA, ValveXchange Inc., Denver, Colorado, USA |
|
|
Background and aim of the study: Mitral valve chordae tendineae are an essential component for correct functioning of the human heart. The microstructural make-up of the chordae is responsible for their tensile properties, and is seen gradually to change with age. However, little is known of the maturation of chordae tendineae and their microstructure. |
muscles. Chordae developed through the formation of gaps in the leaflet tissue. From day 7 on, numerous chordae were seen. As the chordae matured, crimped collagen fibrils were formed and began to align in a longitudinally packed core with increasing density. The collagen fibril crimp period increased significantly with the age of the animal. |
| Structural Changes of Rat Mitral Valve Chordae Tendineae During Postnatal Development | |
Click the above hyperlink to view the article, right click (Ctrl click on a Mac) to open in a new browser window or tab.
Purchase this Article
Please click the button below to purchase this article. Single article purchases are provided at $50.00 per article. Upon clicking the button below, single article user account subscription details are requested and, upon successful payment, a single article user account is created. Single articles are availble in your account for seven days after purchase.
Website by CHP Design, London