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You are here: Contents > 2012 > Volume 21 Number 5 September 2012 > MITRAL VALVE DISEASE > Serum 25-Hydroxyvitamin D Levels are Correlated with Mitral Valve Calcification Score in Patients with Rheumatic Mitral Stenosis

Serum 25-Hydroxyvitamin D Levels are Correlated with Mitral Valve Calcification Score in Patients with Rheumatic Mitral Stenosis

Bunyamin Yavuz, Omer Sen, Onur Sinan Deveci, Kadir Okhan Akin, Kursat Dal, Naim Ata, Derun Taner Ertugrul

Departments of Cardiology, Biochemistry and Internal Medicine, Kecioren Teaching and Research Hospital, Ankara, Turkey

Background and aim of the study: Rheumatic mitral stenosis (RMS) is a chronic disease related to autoimmune heart valve damage after streptococcal infection. Epidemiological evidence supports an association between vitamin D and the susceptibility and severity of autoimmune disorders. The study aim was to assess the serum levels of 25-hydroxyvitamin D and their correlation with Wilkins calcification score in patients with RMS.
Methods: Thirty-four patients with RMS and 29 healthy age- and gender-matched controls were enrolled in the study. All subjects underwent transthoracic echocardiography after a complete medical evaluation and laboratory examination. The planimetric mitral valve area and Wilkins score were evaluated for all patients, and biochemical parameters and serum levels of 25-hydroxyvitamin D and calcitriol were determined.
Results: The mean patient age was similar in the RMS and control groups (50 ± 10 versus 52 ± 10 years; p = NS). The serum level of 25-hydroxyvitamin D

was significantly lower in RMS patients than in controls (8.6 ng/ml; range: 4.9-26.3 ng/ml versus 12.3 ng/ml; range: 4-158 ng/ml; p = 0.031). A significantly moderate inverse correlation was identified between the serum 25-hydroxyvitamin D level and the Wilkins score (r = -0.567, p <0.001), but no correlation was identified between 25-hydroxyvitamin D levels and other echocardiographic parameters of mitral stenosis. The serum level of calcitriol was also significantly lower in RMS patients than in controls (19.8 pg/ml; range: 16.0-54.6 pg/ml versus 26.1 pg/ml; range: 13.2-47.0 pg/ml; p = 0.013).
Conclusion: The study results showed that serum levels of 25-hydroxyvitamin D were significantly lower in RMS patients than in controls, and also correlated with the Wilkins calcification score. Thus, a link may exist between 25-hydroxyvitamin D and the calcification process in RMS.


The Journal of Heart Valve Disease 2012;21:570-575

Serum 25-Hydroxyvitamin D Levels are Correlated with Mitral Valve Calcification Score in Patients with Rheumatic Mitral Stenosis

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