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You are here: Contents > 2012 > Volume 21 Number 5 September 2012 > AORTIC VALVE DISEASE > One-Year Observation of Inflammatory Markers in Patients with Aortic Valve Stenosis who Expressed High or Low Chlamydia pneumoniae Antibody Titers

One-Year Observation of Inflammatory Markers in Patients with Aortic Valve Stenosis who Expressed High or Low Chlamydia pneumoniae Antibody Titers

Jolanta Świerszcz, Jacek. S. Dubiel, Tomasz Milewicz, Józef Krzysiek, Krystyna Sztefko, Danuta Galicka-Latała

Second Department of Cardiology, Department of Gynecological Endocrinology, Chair of Metabolic Diseases Jagiellonian University, Collegium Medicum, Cracow, Department of Clinical Biochemistry University Children’s Hospital, Cracow, Poland

Background and aim of the study: Aortic valve stenosis (AVS) and atherosclerosis can be regarded as two manifestations of the same pathological process. The study aim was to evaluate annually the plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) in AVS patients, and to compare these data in AVS patients with and without high IgG, IgM, and IgA titers against Chlamydia pneumoniae.
Methods: Sixty patients with AVS who had declined the offer of remedial surgery were allocated to groups according to their antibody titers: group A (n = 30, high IgG titer), group B (n = 30, low IgG titer), group C (n = 22, high IgA titer), group D (n = 38, low IgA titer), group E (n = 7, high IgM titer), and group F (n = 53, low IgM titer) Antibody titers, serum levels

of inflammatory markers and echocardiographic scans were monitored at 12-month intervals.
Results: During a one-year observation period, a greater number of patients in group A showed AVS deterioration compared to group B (p <0.02). The mean IgA and IgM titers in group A were higher than in group B, while mean serum CRP and IL-6 levels, and IgG titer, tended to be higher in group C compared to group D. No statistically significant differences were identified in mean serum levels of CRP, IL-6, and TNFα between groups A and B.
Conclusion: The results of the study suggested a possible association between C. pneumoniae infection and the progression of AVS.

The Journal of Heart Valve Disease 2012;21:599-607

One-Year Observation of Inflammatory Markers in Patients with Aortic Valve Stenosis who Expressed High or Low Chlamydia pneumoniae Antibody Titers

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