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You are here: Contents > 2014 > Volume 23 Number 1 January 2014 > MITRAL VALVE DISEASE > Intermediate Results of Transaortic Edge-to-Edge Repair of the Mitral Valve in Patients Undergoing Aortic Valve Replacement

Intermediate Results of Transaortic Edge-to-Edge Repair of the Mitral Valve in Patients Undergoing Aortic Valve Replacement

Christos G. Mihos1, Orlando Santana1, Joseph Lamelas2

1Columbia University Division of Cardiology and 2Division of Cardiac Surgery at the Mount Sinai Heart Institute, Miami Beach, Florida, USA

Background and aim of the study: The study aim was to evaluate the safety and efficacy of a transaortic edge-to-edge mitral valve repair in patients undergoing aortic valve replacement (AVR) who were considered to be at high risk for double-valve surgery.

Methods: All patients deemed to be at high surgical risk for standard double-valve surgery, and who instead underwent AVR with transaortic edge-to-edge mitral valve repair between September 2008 and October 2012 at the authors’ institution, were analyzed retrospectively. Intraoperative transesophageal and follow-up transthoracic echocardiography were performed to evaluate adequacy of the repair and to assess for any recurrence of mitral regurgitation (MR).

Results: A total of 55 patients (mean age 78.4 ± 8.4 years) was identified (45 minimally invasive, 10 median sternotomy). All patients were in NYHA class III-IV. The aortic valve lesion was classified as stenosis (n = 45), insufficiency (n = 6), 

or prosthetic valve insufficiency (n = 4), and the mitral valve lesion as functional (n = 16), degenerative calcification (n = 27), or rheumatic (n = 12). There were four deaths (7%). The median total hospital length of stay was 7 days (IQR 6-11 days). The median preoperative versus postoperative MR grade was moderate-to-severe (3+) (IQR 3-4+) versus 0 (IQR 0-1+) (p <0.001). The median time to follow up echocardiography was 6.5 months (IQR 0.8-12 months). The median preoperative and postoperative versus follow up MR grades were 3+ (IQR 3-4+) versus 1+ (IQR 0-1+) (p <0.001), and 0 (IQR 0-1+) versus 1+ (IQR 0-1+) (p = 0.004), respectively.

Conclusion: In high-risk patients undergoing AVR with grade 3-4+ MR, a transaortic edge-to-edge mitral valve repair may be a safe and effective alternative to conventional double-valve surgery. However, longer-term data are needed to verify this proposal.

The Journal of Heart Valve Disease 2014;23:91-96

Intermediate Results of Transaortic Edge-to-Edge Repair of the Mitral Valve in Patients Undergoing Aortic Valve Replacement

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