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You are here: Contents > 2014 > Volume 23 Number 3 May 2014 > MITRAL VALVE DISEASE > Mitral Valve Regurgitation after Atrial Septal Defect Repair in Adults

Mitral Valve Regurgitation after Atrial Septal Defect Repair in Adults

Shohei Yoshida, Satoshi Numata, Yasushi Tsutsumi, Osamu Monta, Sachiko Yamazaki, Hiroyuki Seo, Takaaki Samura, Hirokazu Ohashi

Fukui Cardiovascular Center, Fukui, Japan

Background and aim of the study: Mitral valve regurgitation (MR) is known to deteriorate following adult atrial septal defect (ASD) repair in the mid to long term. The study aim was to identify the risk factors for this deterioration.

Methods: Between 1995 and 2011, a total of 93 consecutive patients (aged ≥18 years) underwent ASD repair at the authors’ institution. Patients who underwent concomitant procedures, other than tricuspid annuloplasty or maze procedure, were excluded; hence, 74 patients were enrolled in the study. MR was evaluated by transthoracic echocardiography shortly after surgery and subsequently on a regular basis in the outpatient clinic. Risk factors for the deterioration of MR were estimated using Cox proportional hazards regression.

Results: The mean patient age at surgery was 48.0 ± 17.1 years, and 20 patients (27%) had atrial fibrillation (AF) preoperatively. The mean follow up was 6.9 ± 5.5 years. The degree of MR was unchanged or not improved in

54 patients (73.0%) (group 1), but was increased by one grade in 12 patients (16.2%) (group 2), and by two or more grades in eight patients (10.8%) (group 3). At surgery, all patients in group 3 were aged >50 years. In group 3, on echocardiography, the average end-diastolic left ventricular dimension was increased from 41.8 mm to 51.8 mm (p = 0.027), and enlargement of the mitral annulus was noted in seven patients. Four of the group 3 patients required reoperation for MR after ASD repair. The Cox proportional hazards model revealed preoperative AF (p = 0.045, hazard ratio (HR): 11.68, 95% confidence interval (95%CI): 1.05-129.48) and Qp/Qs ≧2.8 (p = 0.015, HR: 9.19, 95%CI : 1.53-55.04) to be independent risk factors of new-onset or aggravated MR (by two or more grades) after ASD repair.

Conclusion: An earlier repair of ASD would be preferable in terms of MR aggravated after ASD repair. For elderly patients with a preoperative high Qp/Qs and AF, mitral valve annuloplasty with ASD repair should considered.

The Journal of Heart Valve Disease 2014;23:310-315

Mitral Valve Regurgitation after Atrial Septal Defect Repair in Adults

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