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You are here: Contents > 2016 > Volume 25 Number 5 September 2016 > RHEUMATIC HEART DISEASE > NT-ProBNP as a Potential Marker of Left Atrial Dysfunction in Rheumatic Mitral Stenosis: Correlation with Left Atrial Function after PBMV

NT-ProBNP as a Potential Marker of Left Atrial Dysfunction in Rheumatic Mitral Stenosis: Correlation with Left Atrial Function after PBMV

Rashi Khare1,3, Sudhanshu Dwivedi2

1Department of Cardiology, RML Hospital and PGIMER, New Delhi, India
2Department of Cardiology, KGMU, Lucknow, India
3Electronic correspondence: rashimedicine@yahoo.com

Background and aim of the study: Rheumatic heart disease is a common reason for cardiovascular morbidity and mortality. Plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are known to rise in patients with MS, but the role of this compound as a non-invasive marker of left atrial (LA) dysfunction is yet to be established. The study aim was to correlate levels of NT-proBNP in patients with rheumatic mitral stenosis (MS), with echocardiographic parameters of LA function including tissue Doppler-derived strain/strain rate (S/Sr) indices, hemodynamic parameters of LA function, before and after percutaneous balloon mitral valvotomy (PBMV) for a follow up of one year.

Methods: The study included 51 patients with severe MS and 10 age- and gender-matched controls. All patients and subjects underwent detailed clinical and echocardiographic evaluation (including LA S/Sr indices) prior to PBMV and at 12 h, one month and one year after PBMV. Venous blood samples were withdrawn to monitor NT-proBNP levels during the same period. LA functions were assessed echocardiographically, using conventional parameters, while S/Sr indices were calculated at mid-LA segments (septal, lateral, anterior and inferior) during ventricular systole, and at early and late diastole. The LA appendage contraction velocity was calculated using transesophageal echocardiography (TEE) and correlated with NT-proBNP levels. The cardiac output (CO) was


calculated invasively. The pulmonary capillary wedge pressure (PCWP), pulmonary artery pressure (PAP) and other parameters were correlated with NT-proBNP levels before and after PBMV.

Results: The mean NT-proBNP level before PBMV was 761.76 ± 213.6 pg/ml, and was 425 pg/ml, 300 pg/ml and 50 pg/ml at one day, one month and one year, respectively (p <0.01). The S/Sr indices at each mid-LA segment (septal, lateral, anterior, and inferior) during ventricular systole (LAs), at early (LAe) and late diastole (LAa) were each significantly lower in patients than in controls (p <0.001). The S/Sr values were improved significantly (p <0.05) in most segments at one day and at one month after PBMV, but after one year the values were increased by >50%, in relation to the NT-proBNP level. There were significant falls in mean PAP and PCWP and a rise in CO, each of which correlated significantly with NTproBNP levels.

Conclusion: NT-proBNP levels correlated significantly with LA dysfunction, and can predict improvements in LA function following PBMV in rheumatic MS for up to one year. Tissue Doppler-derived S/Sr indices may be used to detect fine variations over and above conventional echocardiography, and this may be clinically valuable in the prognosis of MS patients.

The Journal of Heart Valve Disease 2016;25:613-618


NT-ProBNP as a Potential Marker of Left Atrial Dysfunction in Rheumatic Mitral Stenosis: Correlation with Left Atrial Function after PBMV

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