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You are here: Contents > 2016 > Volume 25 Number 6 November 2016 > MITRAL VALVE DISEASE > A Systematic Review and Meta-Analysis of Outcomes Following Mitral Valve Surgery in Patients with Significant Functional Mitral Regurgitation and Left Ventricular Dysfunction

A Systematic Review and Meta-Analysis of Outcomes Following Mitral Valve Surgery in Patients with Significant Functional Mitral Regurgitation and Left Ventricular Dysfunction

Ali Andalib1, Michael Chetrit1, Masha Eberg2, Kristian B. Filion2, Pascal Thériault-Lauzier1, Ruediger Lange3, Jean Buithieu1, Giuseppe Martucci1, Mark Eisenberg2, Steven F. Bolling4, Nicolo Piazza1,3,5

1Department of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada
2Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
3Department of Cardiac Surgery, German Heart Center, Munich, Germany
4Department of Cardiac Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
5Electronic correspondence: nicolopiazza@mac.com

Background and aim of the study: The surgical correction of functional mitral regurgitation (MR) remains challenging and controversial. The study aim was to systematically review the outcomes of surgical mitral valve repair (MVRpr) and mitral valve replacement (MVR) in patients with significant functional MR and left ventricular (LV) dysfunction.

Methods: A meta-analysis was performed of published data acquired from patients with moderate to severe functional MR and LV ejection fraction (LVEF) <40% who underwent surgical MVRpr or MVR. The data were meta-analyzed across studies using Bayesian hierarchical models when feasible.

Results: The search yielded 36 observational studies. The

pooled proportion of operative mortality following MVRpr was 5% (33 studies; 2,231 patients; 95% credible interval (CrI) 4-7%), while that following MVR was 10% (10 studies; 389 patients; 95% CrI 5-18%). For patients undergoing MVRpr, pooled proportions of postoperative cerebrovascular accidents and renal failure were 2% (11 studies; 750 patients; 95% CrI 1-3%) and 9% (11 studies; 756 patients; 95% CrI 5-16%), respectively. The five-year actuarial survival rates following MVRpr across 12 studies ranged from 47% to 78% (median 66%).

Conclusion: In selected patients with significant functional MR and LV dysfunction, surgical MVRpr and MVR can be performed with acceptable intermediate operative mortality risks.

The Journal of Heart Valve Disease 2016;25:696-707

A Systematic Review and Meta-Analysis of Outcomes Following Mitral Valve Surgery in Patients with Significant Functional Mitral Regurgitation and Left Ventricular Dysfunction

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