Effects of Percutaneous Balloon Mitral Valvuloplasty on Plasma B-type Natriuretic Peptide in Rheumatic Mitral Stenosis With and Without Atrial Fibrillation
Department of Cardiology, The First Affiliated Hospital, Zhejang University College of Medicine, Zhejiang, P.R. China
Background and aim of the study: The study aim
was to evaluate the effect of percutaneous balloon mitral valvuloplasty
(PBMV) on plasma B-type natriuretic peptide (BNP) levels in patients
in sinus rhythm (SR) and with atrial fibrillation (AF).
in plasma BNP (DBNP) correlated positively with those
in mLAP (DmLAP) (r = 0.696, p <0.01) and PAP (DPAP) (r = 0.456, p <0.05).
Left ventricular end-diastolic volume (LVEDV) (96.1
± 21.6 versus 111.5 ± 25.2 ml, p <0.01) and stroke volume
(SV) (59.2 ± 15.8 versus 69.0 ± 17.9 ml, p <0.05) augmented
accordingly without any changes in left ventricular end-diastolic pressure
(LVEDP) (p = NS). In contrast, in group AF, BNP levels remained unchanged
(pre-PBMV 111.6 ± 53.4 pg/ml; at 20 min, 122.0 ± 68.7 pg/ml;
at 24 h, 106.1 ± 56.2 pg/ml; respectively, p = NS), while LVEDP
increased (6.4 ± 3.6 versus 8.6 ± 3.2 mmHg, p <0.01),
without any changes in LVEDV and SV (p = NS).