Nanobacteria-Associated Calcific Aortic Valve Stenosis Tomislav M. Jelic, Ho-Huang Chang, Rod Roque, Amer M. Malas, Stafford
G. Warren, Andrei P. Sommer |
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Calcific aortic valve stenosis is the most common valvular disease in developed countries, and the major reason for operative valve replacement. In the US, the current annual cost of this surgery is approximately $1 billion. Despite increasing morbidity and mortality, little is known of the cellular basis of the calcifications, which occur in high-perfusion zones of the heart. The case is presented of a patient with calcific aortic valve stenosis and colonies of progressively mineralized |
nanobacteria in the fibrocalcific nodules of the aortic
cusps, as revealed by transmission electron microscopy. Consistent with
their outstanding bioadhesivity, nanobacteria might serve as causative
agents in the development of calcific aortic valve stenosis. |
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