Lack of Association between Transforming Growth Factor-b1 Gene Polymorphisms and Mitral Valve Prolapse in Taiwan Chinese
Hsiang-Tai Chou MD, Yi-Ru Shi MS, Yuan Hsu BS, Fuu-Jen Tsai MD.

The relationship between transforming growth factor-b1 (TGF-b1) gene C-509T and T869C polymorphisms and mitral valve prolapse (MVP) among the Chinese population in Taiwan was evaluated. There was no significant difference in the distribution of TGF-b1 C-509T genotypes (p = 0.76) and allelic frequencies (p = 0.69) between MVP cases and controls, nor any significant difference in the distribution of TGF-b1 gene T869C genotypes (p = 0.95) and allelic frequencies (p = 0.84) between MVP cases and controls. These data indicate that the C-509T and T869C polymorphisms of the TGF-b1 gene are not suitable genetic markers of MVP in Taiwan Chinese.