Left Ventricular Mass Regression after Aortic Valve Replacement with the Mosaic Bioprosthesis
Walter B. Eichinger MD, Florian Botzenhardt MD, Ralf Günzinger MD, Bernhard M. Kemkes MD, Niels Bleese MD, Andrzej Sosnowski MD, Dominique Maïza MD, Eduardo Otero Coto MD, Robert Bauernschmitt MD, Rüdiger Lange MD

The study aim was to evaluate the hemodynamic performance and extent of left ventricular mass regression after aortic valve replacement with the Mosaic bioprosthesis within the first postoperative year. Between 1994 and 1999, 366 patients at five centers in Europe were followed up with transthoracic echocardiography performed within six days postoperatively, after six months, and at annual intervals thereafter. LV mass decreased significantly in patients with valve sizes 21 to 27 mm. The 19 mm valve group did not show any significant LV mass reduction. Patients with significant LV mass index regression had survival benefits after seven years. Mean pressure gradients and effective orifice areas were very satisfactory for all sizes.