Recurrent Thrombosis of Prosthetic Mitral Valve in Idiopathic Hypereosinophilic Syndrome
Ko Watanabe MD, Olivier Tournilhac MD, Lionel F. Camilleri MD

A 41-year old man with idiopathic hypereosinophilic syndrome had severe mitral regurgitation. He had two subsequent mechanical mitral valve thromboses in the setting of rising eosinophilia. A Carpentier-Edwards bioprosthesis was used for the third valve replacement. Some features of myeloproliferative disease, including chromosome 10 abnormality, were identified. Normal eosinophilic count and disappearance of chromosomal abnormality were achieved with an interferon/ hydroxyurea/prednisone regimen. At 30 months postoperatively, the patient had a normal lifestyle.