This study presents results from 109 patients undergoing isolated aortic valve replacement (AVR) for infective endocarditis. Native valve endocarditis was present in 89 patients (81.6%) and prosthetic valve endocarditis in 20 (18.4%). Active culture-positive endocarditis was present in 53 patients (48.6%). Mechanical valves were implanted in 69 patients (63.3%) and bioprostheses in 40 (36.7%). The operative mortality rate was 10.1%. At ten years, freedom from recurrent infection was 94.2% and freedom from reoperation 83.6%. Biological valve (p = 0.01) and younger age (p = 0.01) were significant adverse parameters for freedom from reoperation. Kaplan-Meier survival, including operative mortality, at five and ten years, was 77.4% and 68.0%, respectively. Staphylococcus aureus (p = 0.008) and older age (p = 0.04) were independent adverse predictors of survival. AVR for endocarditis carries a relatively high operative mortality, but can result in a satisfactory freedom from recurrent infection, reoperation and long-term survival.