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You are here: Contents > 2006 > Volume 15 Number 3 May 2006 > AORTIC VALVE DISEASE > Aortic Valve Calcium Content does Not Predict Aortic Valve Area

Aortic Valve Calcium Content does Not Predict Aortic Valve Area

Emile R. Mohler III1, Elizabeth Medenilla1, Hao Wang2, Craig Scott1

1Department of Medicine, Cardiovascular Division, 2Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA

Background and aim of the study: Aortic stenosis (AS) is a common clinical problem which frequently necessitates aortic valve replacement (AVR). The traditional view of progressive AS is a 1:1 inverse relationship between valve calcium content and aortic valve area (AVA). However, this assumption has been based on subjective estimates of calcification on chest X-radiographic images. The study aim was to evaluate the relationship between AVA as measured with echocardiography compared to calcium quantification using electron beam computed tomography (EBT).
Methods: Sixty-one patients with an AVA between 0.7 and 2.0 cm2 underwent an EBT scan to evaluate the aortic valve calcium content.


Results: The mean (± SD) aortic valve Agatston calcium score was 1,458.4 ± 1,362.2, and for the aortic valve volume score was 1,178.8 ± 1,066.0. The aortic valve Agatston score did not correlate strongly with AVA
(r = -0.34, 95% CI -0.54, -0.09; p = 0.007). The data
pattern appeared curvilinear, with the poorest correlation noted for those patients with moderate and severe aortic valve calcification.
Conclusion: The study findings support the hypothesis that the aortic valve orifice area decreases not only due to calcium accumulation but also to sclerotic processes.
The Journal of Heart Valve Disease 2006;15:322-328

Aortic Valve Calcium Content does Not Predict Aortic Valve Area

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