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You are here: Contents > 2006 > Volume 15 Number 3 May 2006 > MITRAL VALVE DISEASE > Peripheral Blood Levels of Matrix Metalloproteinases in Patients Referred for Percutaneous Balloon Mitral Valve Commissurotomy

Peripheral Blood Levels of Matrix Metalloproteinases in Patients Referred for Percutaneous Balloon Mitral Valve Commissurotomy

Robert J. Garr1, Richard A. Krasuski1, Robert E. Eckart2, Andrew Wang3, Cynthia Pierce3, 

Katherine B. Kisslo3, J. Kevin Harrison3, Thomas M. Bashore3
1Wilford Hall Medical Center, Lackland Air Force Base, Texas, 2Brooke Army Medical Center, Fort Sam, Houston, Texas, 3Duke University Medical Center, Raleigh, North Carolina, USA

Background and aim of the study: Inflammation may play a central role in the progression of stenotic valvular heart disease. Serum levels of matrix metalloproteinases (MMPs), markers of extracellular matrix (ECM) turnover and potential markers of active inflammation, have been recently demonstrated in several inflammatory processes. The present study was designed to examine whether systemic evidence of ECM turnover was present in advanced stenotic mitral valve disease.
Methods: Serum levels of MMP-1, -3 and -9 were measured in 114 patients with mitral stenosis referred for percutaneous balloon mitral valve commissurotomy, and compared to those in 48 healthy, age- and gender-matched controls.




Results: Serum levels of MMP-1, -3 and -9 did not vary according to hemodynamic profile or heart failure class at the time of blood sampling. Levels of MMP-1 and -3 were not significantly different between those patients with mitral stenosis and controls. The level of MMP-9 was significantly higher in patients with mitral stenosis than in controls, and did not appear to be altered by commissurotomy.
Conclusion: Serum levels of MMP-9 were elevated in patients with mitral stenosis, providing further evidence that inflammation and ECM remodeling plays an important role in the pathophysiology of valvular heart disease.
The Journal of Heart Valve Disease 2006;15:369-374

Peripheral Blood Levels of Matrix Metalloproteinases in Patients Referred for Percutaneous Balloon Mitral Valve Commissurotomy

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