Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations
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Sinan Cerşit1,3, Emrah Bayam1, Sabahattin Gündüz1, Mehmet Özkan1,2 1Kartal Koşuyolu Heart Training and Research Hospital, Department of Cardiology, İstanbul, Turkey2School of Health Sciences, University of Ardahan, Ardahan, Turkey 3Electronic correspondence: sinancersit@hotmail.com |
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Mitral annuloplasty ring thrombosis is an extremely infrequent pathology, for which no evidence-based antithrombotic management has yet been described. Herein is presented a case of heterozygous Factor V Leiden (FVL) and hyperhomocysteinemia with homozygous methylenetetrahydrofolate reductase (MTHFR) mutations that caused early thrombosis of the mitral annuloplasty ring. The clinical management and antithrombotic treatment of the patient, and the implications of hyperhomocysteinemia, are discussed. |
Video 3: 2D video showing the morphologic change of mitral annuloplasty ring thrombus after prolonged UFH infusion. The Journal of Heart Valve Disease 2017;26:585-588 |
| Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations | |
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