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You are here: Contents > 2010 > Volume 19 Number 6 November 2010 > MISCELLANEOUS > The Effect of Amiodarone on Cardiac Rhythm after Cardiopulmonary Bypass in Patients with Atrial Fibrillation

The Effect of Amiodarone on Cardiac Rhythm after Cardiopulmonary Bypass in Patients with Atrial Fibrillation

Sun Jie, Chen Yu, Lu Xiaohu, Qian Yanning, Ding Zhengnian, Tang Xiaoyang 

Departments of Anesthesiology and Cardio-thoracic Surgery, Jiangsu Province Hospital, Nanjing Medical University, Nanjing 210029, P. R. China

Background and aim of the study: The intraoperative use of amiodarone in patients with atrial fibrillation (AF) undergoing valvular heart surgery was unclear. Hence, a randomized clinical trial was designed to evaluate the effect of amiodarone on cardiac recovery and rhythm following mitral valve surgery.
Methods: A total of 120 elective mitral valve replacement patients with AF received either amiodarone (5 mg/kg) or the same volume of saline during cardiopulmonary bypass (CPB), in a randomized manner. Cardiac recovery was assessed by the heart auto re-beat ratio, the time from reperfusion to heart beat,

the post-reperfusion rhythm, pacemaker use, and vasoactive drug use.
Results: A higher heart auto re-beat ratio, higher sinus rhythm ratio, lower electric defibrillation ratio and less dopamine usage were found in the amiodarone treatment group. However, the proportion of temporary pacemaker use was lower in the control group.
Conclusion: Amiodarone had a good effect on cardiac recovery and the rhythm of AF patients after CPB.


The Journal of Heart Valve Disease 2010;19:786-788

The Effect of Amiodarone on Cardiac Rhythm after Cardiopulmonary Bypass in Patients with Atrial Fibrillation

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