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You are here: Contents > 2010 > Volume 19 Number 6 November 2010 > CASE REPORTS > Severe Tricuspid Regurgitation in a Patient Receiving Low-Dose Cabergoline for the Treatment of Acromegaly

Severe Tricuspid Regurgitation in a Patient Receiving Low-Dose Cabergoline for the Treatment of Acromegaly

Cemil Izgi, Hasan Feray, Cihan Cevik, Yelda Saltan, Denyan Mansuroglu, Kenneth Nugent 

Departments of Cardiology and Cardiovascular Surgery, Gaziosmanpasa Hospital, Istanbul, Turkey, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

Cabergoline, an ergot-derived dopamine receptor agonist, is used widely in the treatment of Parkinson’s disease (PD) and hyperprolactinemia, but may cause heart valve fibrosis, retraction, and clinically significant regurgitation in PD patients. While cabergoline has been used at much lower doses in patients with hyperprolactinemia, controversy persists as to whether it may cause heart valve disease in this situation. Cabergoline is also used in acromegaly at doses similar to those used in hyperprolactinemia. The case is reported of a female patient with acromegaly who had been taking low-dose (0.5 mg/day) cabergoline for one year, and pre

sented with signs and symptoms of right-sided heart failure. Echocardiography revealed a thickened and retracted tricuspid valve associated with severe tricuspid regurgitation and enlargement of the right-heart chambers. The morphology of the tricuspid valve was typical for cabergoline-related valvulopathy. Cabergoline may not be totally safe even at lower doses, and close echocardiographic monitoring is recommended in patients receiving cabergoline treatment, regardless of the dose level employed.


The Journal of Heart Valve Disease 2010;19:798-801

Severe Tricuspid Regurgitation in a Patient Receiving Low-Dose Cabergoline for the Treatment of Acromegaly

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