Marcelo Katz, Flavio Tarasoutchi, Antonio Eduardo Pereira Pesaro, Renato D. Lopes, Guilherme Sobreira Spina, Marcelo Luiz Campos Vieira, Max Grinberg Heart Institute, University of Sao Paulo Medical School, Brazil, Albert Einstein Hospital, Sao Paulo, Brazil, Duke Clinical Research Institute, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA |
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Background and aim of the study: The natriuretic peptides, brain natriuretic peptide (BNP) and its N-terminal prohormone (NT-proBNP), can be used as diagnostic and prognostic markers for aortic stenosis (AS). However, the association between BNP, |
replacement, and 13 patients (20%) were medically managed without surgical interventions. Mortality rates were 13.7% in the surgical group and 62% in the medically managed group (p <0.001). Patients with higher plasma BNP (>135 pg/ml) and NT-proBNP (>1,150 pg/ml) levels at baseline had a greater risk of long-term mortality (hazard ratio [HR] 3.2, 95% confidence interval [CI] 1.1–9.1; HR 4.3, 95% CI 1.4-13.5, respectively). After adjusting for important covariates, both BNP and NT-proBNP remained independently associated with long-term mortality (HR 2.9, 95%CI 1.5–5.7; HR 1.8, 95%CI 1.1–3.1, respectively). |
Natriuretic Peptides and Long-Term Mortality in Patients with Severe Aortic Stenosis |
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