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You are here: Contents > 2012 > Volume 21 Number 4 July 2012 > AORTIC VALVE DISEASE > Effects of Spironolactone Treatment on an Experimental Model of Chronic Aortic Valve Regurgitation

Effects of Spironolactone Treatment on an Experimental Model of Chronic Aortic Valve Regurgitation

Adnane Zendaoui, Dominic Lachance, Élise Roussel, Jacques Couet, Marie Arsenault

Groupe de Recherche sur les Valvulopathies, Centre de Recherche de l’Institut universitaire de Cardiologie et pneumologie de Québec, Université Laval, Québec, Canada

Background and aim of the study: Aortic regurgitation (AR) is a disease for which there is currently no effective medical treatment. It has been shown previously in an experimental model of AR that the renin-angiotensin-aldosterone system (RAAS) plays a major role, and that medications blocking the RAAS are effective to protect against left ventricular (LV) hypertrophy and also help to maintain a normal systolic function. The role of aldosterone receptor blockers in this disease has never been evaluated. Thus, the effects were studied of the aldosterone receptor blocking agent spironolactone in a model of chronic AR in rats.
Methods: The effects of a six-month treatment with spironolactone were evaluated in adult Wistar rats

with severe AR, compared to sham-operated and untreated AR animals.
Results: Spironolactone treatment decreased the total heart weight. In addition, the LV expression of atrial natriuretic peptide mRNA was decreased by spironolactone treatment, as was the expression of collagen 1 and LOX1 mRNAs. Left ventricular fibrosis was decreased by spironolactone treatment.
Conclusion: Spironolactone protected against volume-overload cardiomyopathy in this model of aortic valve regurgitation. The predominant protective effect was a decrease in myocardial fibrosis.

The Journal of Heart Valve Disease 2012;21:478-486

Effects of Spironolactone Treatment on an Experimental Model of Chronic Aortic Valve Regurgitation

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