Petra E. Dijkman, Anita Driessen-Mol, Linda M. de Heer, Jolanda Kluin, Lex A. van Herwerden, Berhard Odermatt, Frank P. T. Baaijens, Simon P. Hoerstrup Department of Biomedical Engineering, Eindhoven University of Technology, the Netherlands, Department of Cardiothoracic Surgery, University Medical Center Utrecht, the Netherlands, Department of Pathology, University Hospital Zürich, Switzerland, Clinic for Cardiovascular Surgery and Swiss Centre for Regenerative Medicine, University and University Hospital Zürich, Switzerland |
|
Background and aim of the study: Living tissue-engineered heart valves (TEHVs) based on rapidly degrading scaffolds and autologous cells might overcome the limitations of today’s valve substitutes. Following minimally invasive trans-apical implantation into an ovine model, TEHVs showed adequate in-vivo functionality, but a thickening of the leaflets was observed. In order to evaluate the impact of the substantial tissue deformations of TEHVs associated with the crimping procedure during minimally invasive delivery, trans-apical and conventional implantation technologies were compared in an ovine model. |
eight weeks. The tissue compositions of the explanted TEHVs and corresponding control valves were analyzed. |
Trans-Apical versus Surgical Implantation of Autologous Ovine Tissue-Engineered Heart Valves |
Click the above hyperlink to view the article, right click (Ctrl click on a Mac) to open in a new browser window or tab.
Please click the button below to purchase this article. Single article purchases are provided at $50.00 per article. Upon clicking the button below, single article user account subscription details are requested and, upon successful payment, a single article user account is created. Single articles are availble in your account for seven days after purchase.