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You are here: Contents > 2002 > Volume 11 Number 4 July 2002 > TISSUE ENGINEERING AND MOLECULAR BIOLOGY > Localization of Immunoreactive Endothelin and Characterization of its Receptors in Aortic Cusps

Localization of Immunoreactive Endothelin and Characterization of its Receptors in Aortic Cusps

Martin Misfeld, Karen Morrison, Hans-H. Sievers, Magdi H. Yacoub, Adrian H Chester

Endothelin (ET) can contract aortic valve cusp tissue. An attempt was made to characterize the receptors that mediate this response, and to localize ET in the aortic valve cusps. ET-mediated contraction occurs via by both

ETA and ETB receptor subtypes. Immunoreactive ET is present in endothelial cells on both sides of the aortic cusps. The physiological and/or pathophysiological role for ET and its receptors require further investigation.

Localization of Immunoreactive Endothelin and Characterization of its Receptors in Aortic Cusps

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