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You are here: Contents > 2002 > Volume 11 Number 4 July 2002 > TISSUE ENGINEERING AND MOLECULAR BIOLOGY > Lack of Association between Transforming Growth Factor-b1 Gene Polymorphisms and Mitral Valve Prolapse in Taiwan Chinese

Lack of Association between Transforming Growth Factor-b1 Gene Polymorphisms and Mitral Valve Prolapse in Taiwan Chinese

Hsiang-Tai Chou MD, Yi-Ru Shi MS, Yuan Hsu BS, Fuu-Jen Tsai MD

The relationship between transforming growth factor-b1 (TGF-b1) gene C-509T and T869C polymorphisms and mitral valve prolapse (MVP) among the Chinese population in Taiwan was evaluated. There was no significant difference in the distribution of TGF-b1 C-509T genotypes (p = 0.76) and allelic frequencies (p = 0.69) between MVP cases and controls, nor any significant

difference in the distribution of TGF-b1 gene T869C genotypes (p = 0.95) and allelic frequencies (p = 0.84) between MVP cases and controls. These data indicate that the C-509T and T869C polymorphisms of the TGF-b1 gene are not suitable genetic markers of MVP in Taiwan Chinese.

Lack of Association between Transforming Growth Factor-b1 Gene Polymorphisms and Mitral Valve Prolapse in Taiwan Chinese

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