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You are here: Contents > 2014 > Volume 23 Number 5 September 2014 > INFECTIVE ENDOCARDITIS > Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Infective Endocarditis: In-Hospital and Long-Term Clinical Results

Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Infective Endocarditis: In-Hospital and Long-Term Clinical Results

Mehmet Bozbay1, Murat Ugur2, Huseyin Uyarel3, Gokhan Cicek2, Bayram Koroglu2, Eyyup Tusun2, Murat Sunbul1, Ahmet Murat2, Ibrahim Sari1, Mehmet Eren2

1Marmara University Faculty of Medicine, Department of Cardiology, Istanbul, 2Istanbul Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, Department of Cardiology, Istanbul, 3Bezmialem Vakıf University Faculty of Medicine, Department of Cardiology, Istanbul, Turkey

Background and aim of the study: The neutrophil-tolymphocyte ratio (NLR) is an independent predictor of poor prognosis in different clinical conditions such as infectious and cardiovascular diseases. It was hypothesized that a patient’s admission NLR would be predictive of an adverse clinical outcome in cases of infective endocarditis (IE).

Methods: A total of 171 patients with IE was enrolled retrospectively, and allocated to two tertiles based on admission NLR values. The high-NLR group (n = 76) was defined as having an NLR value in the third tertile (>5.46), and the low-NLR group (n = 95) as having a value in the lower two tertiles (≤5.46).


Results: Patients in the high-NLR group had a significantly higher incidence of in-hospital mortality than the low-NLR group (39.4% versus 18.9%, p = 0.003). A high NLR was found to be an independent predictor of in-hospital mortality (odds ratio 2.53, 95% confidence interval 1.19-5.3; p = 0.01). The mean follow up was 25.5 months, and long-term follow up mortality was similar in both groups (12.9% versus 19.5%; p = 0.33).

Conclusion: A high NLR at admission is associated with increased in-hospital mortality in patients with IE. During the long-term follow up, NLR showed no predictive indication of mortality.

The Journal of Heart Valve Disease 2014;23:617-623

Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Infective Endocarditis: In-Hospital and Long-Term Clinical Results

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