Share this page on LinkedIn
Share This Page on Google+
Share This Page on Twitter
tell someone about this page print this page
You are here: Contents > 2015 > Volume 24 Number 4 July 2015 > AORTIC VALVE DISEASE > Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction

Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction

Duo Huang, Pak-Hei Chan Lam, Puigi Catherine Shea, Kai-Hang Yiu, Hung-Fat Tse, Chung-Wah Siu

Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong

Patients with severe aortic stenosis (AS) and left ventricular systolic dysfunction pose a significant challenge to the managing physician. Conventional pharmacological therapy for systolic heart failure has not been proven beneficial in this setting. Ivabradine, a selective current inhibitor, decreases the spontaneous firing rate of sinoatrial nodal cells, thereby reducing the heart rate, and has been shown

to reduce a composite end-point of heart failure hospitalization and mortality in patients with impaired left ventricular function. Herein are reported details of the hemodynamic effects and clinical outcome of ivabradine treatment in an 86-year-old man with severe AS and severe left ventricular systolic function.

The Journal of Heart Valve Disease 2015;24:433-435


Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction

Click the above hyperlink to view the article, right click (Ctrl click on a Mac) to open in a new browser window or tab.

Purchase this Article

Please click the button below to purchase this article. Single article purchases are provided at $50.00 per article. Upon clicking the button below, single article user account subscription details are requested and, upon successful payment, a single article user account is created. Single articles are availble in your account for seven days after purchase.