Share this page on LinkedIn
Share This Page on Google+
Share This Page on Twitter
tell someone about this page print this page
You are here: Contents > 2016 > Volume 25 Number 3 May 2016 > AORTIC VALVE DISEASE > Quantitative Doppler for Estimation of Paravalvular Leakage after Transcatheter Aortic Valve Implantation

Quantitative Doppler for Estimation of Paravalvular Leakage after Transcatheter Aortic Valve Implantation

Luigi F. M. Di Martino1,2, Osama I. I. Soliman1,3, Wim B. Vletter1, Ben Ren1, Ton de Vries3, Tjebbe W. Galema1, Nicolas M. Van Mieghem1, Peter P. de Jaegere1, Marcel L. Geleijnse1,4

1Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands
2Department of Cardiology, Ospedali Riuniti, Università degli studi di Foggia, Foggia, Italy
3Cardialysis Cardiovascular Core Laboratory, Rotterdam, the Netherlands
4Electronic correspondence: m.geleijnse@erasmusmc.nl

Background and aim of the study: The echocardiographic grading of paravalvular aortic leakage (PVL) after transcatheter aortic valve implantation (TAVI) severity is challenging. The study aim was to assess the value of quantitative Doppler echocardiography to monitor PVL severity.

Methods: A total of 100 subjects was enrolled in the study, including 65 consecutive patients who had undergone TAVI with a CoreValve prosthesis and without valvular aortic regurgitation, and 35 normal controls. The PVL volume was calculated using the quantitative Doppler method as the difference of left and right ventricular stroke volume (SV). PVL severity was assessed both visually and quantitatively as the circumferential extent on a short-axis view (SAX).

Results: The inter-observer variabilities for SVs in TAVI patients were disappointing: 14 ± 11% for the left


ventricular SV and 18 ± 14% for right ventricular SV. The correlation (r2) between the averaged regurgitant PVL volume and circumferential SAX extent of PVL was 0.02 (p = NS). The relationship between PVL volumes and categories, defined quantitatively by the circumferential SAX extent of PVL and qualitatively by visual assessment of severity of PVL were poor. The results improved when only patients with optimal quality images were included but were still statistically non-significant.

Conclusion: The relationship between calculated PVL volume in TAVI patients and other estimates of PVL severity was poor, most likely due to intrinsic errors made in the quantitative Doppler method. Therefore, one should be prudent to include the quantitative Doppler method in TAVI patients in clinical trials and clinical decision-making, in particular in patients with reduced image quality.

The Journal of Heart Valve Disease 2016;25:289-295


Quantitative Doppler for Estimation of Paravalvular Leakage after Transcatheter Aortic Valve Implantation

Click the above hyperlink to view the article, right click (Ctrl click on a Mac) to open in a new browser window or tab.

Purchase this Article

Please click the button below to purchase this article. Single article purchases are provided at $50.00 per article. Upon clicking the button below, single article user account subscription details are requested and, upon successful payment, a single article user account is created. Single articles are availble in your account for seven days after purchase.