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You are here: Contents > 2017 > Volume 26 Number 2 March 2017 > MITRAL VALVE DISEASE > Incidence and Clinical Impact of Cerebral Lesions after the MitraClip® Procedure

Incidence and Clinical Impact of Cerebral Lesions after the MitraClip® Procedure

Sebastian Barth1,6, Karsten Hamm1, Stefan Fodor2, Wilko Reents3, Sebastian Kerber1, Philipp Halbfass1, Martina B. Hautmann1, Bernhard Schieffer5, Hassan Soda4

1Department of Cardiology, Cardiovascular Center Bad Neustadt, Germany
2Department of Radiology, Cardiovascular Center Bad Neustadt, Germany
3Department of Cardiac Surgery, Cardiovascular Center Bad Neustadt, Germany
4Department of Neurology, Cardiovascular Center Bad Neustadt, Germany
5Department of Cardiology, University of Marburg, Germany
6Electronic correspondence: sebastian.barth@kardiologie-bad-neustadt.de

Background and aim of the study: Clinically silent brain injury detected with cerebral magnetic resonance imaging (MRI) is well known after various cardiovascular interventions. Thus far, only one study has examined the periprocedural risk of cerebral ischemic events in patients undergoing percutaneous mitral valve reconstruction. The study aim was to examine the incidence and clinical impact of cerebral embolic events in patients undergoing percutaneous mitral valve reconstruction using the MitraClip® system.

Methods: Thirteen eligible high-risk patients without contraindications for MRI underwent MitraClip treatment at the authors’ institution. Neurological testing with the assessment of global cognitive function was performed three days before and two days after the procedure. All patients underwent cerebral diffusion-weighted MRI (DWI)

two days after the procedure.

Results: In nine patients, post-interventional MRI revealed newly acquired microembolic cerebral lesions. At follow up MRI scans recorded at 307 ± 270 days after the procedure, ischemic scars were not detectable in any patient. Two patients with five or more new cerebral lesions in DW-MRI showed a significant decline in their test scores.

Conclusion: The MitraClip procedure results in acute cerebral lesions in the vast majority of patients. All lesions seen on DWI post-procedure resolved completely, but the number of lesions may have had an impact on cognitive function.

The Journal of Heart Valve Disease 2017;26:175-184


Incidence and Clinical Impact of Cerebral Lesions after the MitraClip® Procedure

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