Unexpected Problems of Antithrombotic Therapy with An Unusual Side Effect of Vitamin K Antagonists after Mitral Valve Replacement
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Benjamin Marchandot1,2, Nathan Messas1, Laurence Jesel1, Annie Trinh1, Marion Kibler1, Antje Reydel1, Patrick Ohlmann1, Olivier Morel1 1Department of Cardiology, University Hospitals of Strasbourg, Nouvel Hôpital Civil, Strasbourg, France |
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| Except for bleeding complications, vitamin K antagonists (VKAs) are known to have few undesirable side effects. Herein is presented the case of a 45-year-old woman in whom liver damage was induced by fluindione and warfarin after mitral valve replacement. Hepatotoxicity is a rare complication of VKAs, both in the French National and Drug Safety registry and the medical literature. A diagnosis of VKA-induced drug damage was confirmed |
by the absence of other etiologies, the chronological sequence, recurrence after re-exposure to VKA, and rapid improvements after discontinuation of the drug. Despite possible cross-reactions between VKAs, the re-introduction of acenocoumarol was successfully achieved, with no recurrence of biological disturbances.
The Journal of Heart Valve Disease 2017;26:309-313 |
| Unexpected Problems of Antithrombotic Therapy with An Unusual Side Effect of Vitamin K Antagonists after Mitral Valve Replacement | |
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