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You are here: Contents > 2017 > Volume 26 Number 5 September 2017 > CASE REPORTS > Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations

Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations

Sinan Cerşit1,3, Emrah Bayam1, Sabahattin Gündüz1, Mehmet Özkan1,2

1Kartal Koşuyolu Heart Training and Research Hospital, Department of Cardiology, İstanbul, Turkey
2School of Health Sciences, University of Ardahan, Ardahan, Turkey
3Electronic correspondence: sinancersit@hotmail.com

Mitral annuloplasty ring thrombosis is an extremely infrequent pathology, for which no evidence-based antithrombotic management has yet been described. Herein is presented a case of heterozygous Factor V Leiden (FVL) and hyperhomocysteinemia with homozygous methylenetetrahydrofolate reductase (MTHFR) mutations that caused early thrombosis of the mitral annuloplasty ring. The clinical management and antithrombotic treatment of the patient, and the implications of hyperhomocysteinemia, are discussed.


Video 1: Mobile 9-mm thrombus of mitral annuloplasty ring on two-dimensional (2D) transesophageal echocardiography.

Video 2: Mitral annuloplasty ring thrombus on real time three-dimensional (RT-3D) transesophageal echocardiography.

Video 3: 2D video showing the morphologic change of mitral annuloplasty ring thrombus after prolonged UFH infusion.

The Journal of Heart Valve Disease 2017;26:585-588


Early Thrombosis of a Mitral Annuloplasty Ring in a Patient with MTHFR and Factor V Leiden Mutations

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