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You are here: Contents > 2018 > Volume 27 Number 1 January 2018 > DEVICE EVALUATION > Early Hemodynamic Performance of the Crown PRT Aortic Prosthesis: A Prospective Study

Early Hemodynamic Performance of the Crown PRT Aortic Prosthesis: A Prospective Study

Simon M. Duggan1,2, Syed Sadeque1, Danai Karamanou1, Kareem Salhiyyah1, Suresh Giritharan1, Dimitrios Pousios1, Szabolcs Miskolczi1, Clifford W. Barlow1

1Wessex Cardiothoracic Centre, Southampton General Hospital, Tremona Road, Southampton, UK
2Electronic correspondence: drsimonduggan@gmail.com

Background and aim of the study: Currently, only limited data are available on the rate of hemodynamic progression with clinical outcome in patients receiving the latest Crown PRT aortic prosthesis. The study aim was to report clinical and hemodynamic outcomes in 55 consecutive patients for a follow up of up to one year after Crown PRT implantation.

Methods: Between February and September 2015, a total of 55 patients (34 males, 21 females; mean age 77.3 ± 1.2 years) underwent aortic valve replacement (AVR) with the latest LivaNova Crown PRT bioprosthesis at the authors’ institution. Left ventricular function was preserved in 79% of patients. Data relating to the patients’ clinical, echocardiographic and functional capacities were obtained prospectively.

Results: There were no in-hospital deaths. Significant perioperative complications included stroke (3.6%), atrial

fibrillation (27%), and permanent pacemaker insertion (1.8%). Pre-discharge echocardiography demonstrated peak (PG) and mean (MG) transprosthetic gradients of 24.4 ± 10.4 mmHg and 12.9 ± 6.2 mmHg, respectively. The Doppler velocity index (DVI) was 0.49 ± 0.13, and the effective orifice area index (EOAi) 0.89 ± 0.12 cm2/m2. At a mean follow up of 1.3 ± 0.3 years, the transprosthetic gradients, DVI and EOAi were not significantly different from postoperative or pre-discharge values. The patients’ NYHA status was I or II in 95% of cases, and the mean left ventricular mass had decreased by 36% at the end of follow up.

Conclusion: The Crown PRT is an effective bioprosthesis, with a low incidence of valve-related complications comparable to those of other current bioprostheses. The bioprosthesis demonstrated satisfactory results in terms of hemodynamics and freedom from reoperation.

The Journal of Heart Valve Disease 2018;27:87-96


Early Hemodynamic Performance of the Crown PRT Aortic Prosthesis: A Prospective Study

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