Introduction: Acute cholecystitis is one of the most common surgical emergencies worldwide. Early laparoscopic cholecystectomy (ELC), performed within 72 hours of symptom onset, has been increasingly recommended over delayed surgery. However, concerns remain regarding operative difficulty, conversion rates, and complications. This study evaluates the safety and efficacy of early laparoscopic cholecystectomy in acute cholecystitis Materials and Methods: A prospective observational study was conducted on 120 patients diagnosed with acute calculous cholecystitis. Patients underwent laparoscopic cholecystectomy within 72 hours of admission. Demographic data, operative time, intraoperative findings, conversion rates, postoperative complications, and length of hospital stay were recorded. Statistical analysis was performed using SPSS version 25. A p-value <0.05 was considered significant. Results: Among 120 patients, 70 (58.3%) were female and 50 (41.7%) were male. The mean operative time was 75 ± 18 minutes. Conversion to open surgery occurred in 8 (6.7%) cases. Postoperative complications were observed in 10 (8.3%) patients, with surgical site infection being the most common. The mean hospital stay was 3.2 ± 1.1 days. No mortality was recorded. Conclusion: Early laparoscopic cholecystectomy is a safe and effective treatment for acute cholecystitis, associated with low conversion rates, minimal complications, and shorter hospital stay. It should be considered the standard of care in hemodynamically stable patients.