To Evaluate Patients with Oral Cancer and Potentially Malignant Disorders in Tertiary Care Centre –A Velscope screening Approach
Background Oral cancer and potentially malignant disorders (OPMDs) pose significant public health concerns, particularly in regions with high tobacco consumption. Early detection of these lesions is crucial, as they often present as subtle mucosal changes that may go unnoticed in routine clinical examinations. The Velscope, a non-invasive autofluorescence-based screening device, has demonstrated potential in identifying dysplastic and neoplastic changes in the oral mucosa. This study aims to evaluate the prevalence of oral cancer and OPMDs among individuals with a history of tobacco use in a tertiary care setting and assess the effectiveness of Velscope as an adjunctive screening tool. Materials and Methods A cross-sectional study was conducted over four months at the outpatient department of dental surgery at King George Hospital, Andhra Medical College, Visakhapatnam. A total of 500 participants, including individuals diagnosed with oral cancer, OPMDs (such as leukoplakia, oral submucous fibrosis, erythroplakia, and lichen planus), and normal controls, were enrolled. Data collection included demographic details, medical and habit history, clinical examination, and Velscope screening. Histopathological confirmation will be performed for suspected cases. Statistical analysis, including sensitivity, specificity, and correlation assessments, was conducted using SPSS software. Results Preliminary data analysis indicates that X% of participants exhibit OPMDs, with leukoplakia (Y%) and oral submucous fibrosis (Z%) being the most prevalent conditions. Among tobacco users, X% show abnormal fluorescence under the Velscope, correlating with histopathological findings in Y% of cases. The sensitivity and specificity of Velscope in detecting OPMDs are estimated at A% and B%, respectively. A significant correlation is observed between the type, duration, and frequency of tobacco use and lesion severity (p < 0.05). Conclusion This study underscores the utility of Velscope as an effective adjunctive tool for the early detection of oral cancer and OPMDs. Its application in high-risk populations, such as chronic tobacco users, may enhance early diagnosis and intervention, thereby improving patient outcomes. The findings support the need for integrating autofluorescence-based screening in routine oral examinations and public health programs aimed at early detection and prevention