Introduction: Chronic Kidney disease (CKD) is renal damage for ≥3 months, defined by structural or functional deformities of renal (clinical deformities or deformities of imaging or the structure of blood), with or without reduced GFR.  Aim and Objectives Correlation Between Antioxidant Status and Microalbuminuria in Chronic Kidney Disease Patients Material and Methods:  This is an Observational or cross-sectional study conCKD patients from outpatient clinics or hospitals, Index Medical College. Patients diagnosed with CKD stages 1–5, based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Demographic and Clinical Data: Collect information on age, gender, duration of CKD, comorbidities, medications, and lifestyle factors. Antioxidant Status Assessment: Measure antioxidant biomarkers such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and total antioxidant capacity (TAC) using validated assays. Result The mean age of the study population is 55.3 years, with a standard deviation of 12.4 years, indicating a relatively wide age range. The study population is nearly evenly distributed between males (52%) and females (48%). The majority of participants (45%) are in CKD Stage 3, which is characterized by moderate kidney damage (eGFR 30–59 mL/min/1.73 m²). The mean duration of CKD is 6.2 years, with a standard deviation of 4.1 years, indicating variability in disease duration among participants. Mean Level of Superoxide Dismutase (SOD) is 12.3 ± 3.2 U/mL. Mean Level of Catalase is 45.6 ± 10.4 U/mL. Glutathione Peroxidase (GPx) Mean Level is 8.7 ± 2.1 U/mL and Total Antioxidant Capacity (TAC) were 1.2 ± 0.3 mmol/L. Superoxide Dismutase (SOD) Levels: SOD levels decrease from 14.2 U/mL in Stage 1 to 9.2 U/mL in Stage 5. Catalase levels show a gradual decline from 50.1 U/mL (Stage 1) to 36.8 U/mL (Stage 5). Glutathione Peroxidase (GPx) Levels drop from 10.2 U/mL in Stage 1 to 6.8 U/mL in Stage 5. Conclusion This study demonstrates a significant negative correlation between antioxidant status and microalbuminuria in CKD patients, consistent with previous research. The findings highlight the role of oxidative stress in CKD progression and suggest that interventions targeting oxidative stress may help reduce microalbuminuria and slow disease progression.