Sepsis is a life-threatening complication of infection and characterized by physiologic, pathologic, and biochemical abnormalities. It is the tenth-most-common cause of death globally and the most common cause of death in patients with infections, especially when sepsis is not identified and treated promptly. Early treatment of sepsis improves patients’ mortality and outcome. Serum lactate level is a sensitive but nonspecific indicator of metabolic stress. A rising lactate value is associated with a higher mortality. The prediction performance of the combination of qSOFA and admission lactate was comparable to full version of SOFA. qSOFA with admission lactate could be a convenient, valuable, and practical tool for prognostic prediction. OBJECTIVES: The aim was to estimate the levels of serum lactate in sepsis patients, to study the prognostic accuracy of serum lactate, QSOFA score AND SOFA score in sepsis and to study lactate levels as an independent prognostic predictor in sepsis . METHODS: The study is conducted in Department of General Medicine at HIMS Hassan. After finalizing the patients to be included in our study, we collect clinical, laboratory, and radiological data from their medical records including demographic data, age, sex, chief complaints, past medical history, and vital signs. Statistical analysis was done by using SPSS software. RESULTS:  The mean age of the study population is 57.167 ± 9.86 years. 64.2% (77) patients were males showing a male predominance in the study, and 35.8% (45) patients were females. In our study population, 40.8% of patients had Diabetes mellitus, 28.3% of patients had Hypertension. Forty-four percent of patients had smoking history and 31.7% patients had history of alcohol consumption. the most common primary focus of sepsis was respiratory system (46.7%). The mean lactate level of our study population was 2.77 mmol/L. The mortality rate of the study population is 18.3%. The sensitivity of predicting mortality with a lactate level of ≥3.33mmol/L is 86.4% and specificity is 82.7%.CONCLUSION: Sepsis with multi-organ dysfunction syndrome (MODS) is a common cause of Intensive Care Unit (ICU) mortality and morbidity. qSOFA score of >2 predicts the higher chances of mortality. Lactate levels above 3.33mmol/L has a high sensitivity and specificity in predicting the mortality of the patient.Our study concludes that lactate is a good prognostic factor and is equally as qSOFA in adult patients with sepsis.