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Research Article | Volume 26 Issue 1 (, 2021) | Pages 1 - 5
Pharmacological Approaches to Preventing Heart Valve Calcification
Jeong W.S.
 ,
Kim Y.J.
 ,
Lim H.-G.
 ,
Jung S.
 ,
Lee J.R.
Under a Creative Commons license
Open Access
Received
Jan. 5, 2020
Revised
April 10, 2020
Accepted
Sept. 15, 2020
Published
Dec. 30, 2020
Abstract

Heart valve calcification (HVC) is a common degenerative process leading to valvular heart disease (VHD), particularly aortic stenosis. The pathological process involves the active deposition of calcium in the valve tissues, leading to stiffening and functional impairment. This article reviews the current understanding of the mechanisms behind heart valve calcification and explores emerging pharmacological approaches aimed at preventing or slowing its progression.

Keywords
Heart valve calcification
Pharmacological therapy
Aortic stenosis
Calcific aortic valve disease
Statins
Bisphosphonates
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Journal of Heart Valve Disease
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