The Role of Extracellular Matrix Remodeling in Valve Disease Progression

doi:N/A

Contents

Abstract
Keywords

Download XML

912 Views

2 Downloads

Share this article

Research Article | Volume 28 Issue 1 (, 2023) | Pages 1 - 5

The Role of Extracellular Matrix Remodeling in Valve Disease Progression

Kalra A.

Pedersen W.R.

Mackey-Bojack S.M.

Duncanson E.R.

Harris K.M.

Under a Creative Commons license

Open Access

Received

Feb. 13, 2022

Revised

June 17, 2022

Accepted

Oct. 20, 2022

Published

Dec. 30, 2022

Abstract

Extracellular matrix (ECM) remodeling is a fundamental process in the pathogenesis of heart valve diseases. This review examines the role of ECM remodeling in valve disease progression, highlighting the molecular mechanisms, key regulatory factors, and clinical implications. We discuss how alterations in ECM composition and structure contribute to the development and progression of various heart valve diseases, including aortic stenosis, mitral regurgitation, and tricuspid valve disorders. The review also explores potential therapeutic strategies targeting ECM remodeling to mitigate valve disease progression.

Keywords

Extracellular matrix

Heart valve disease

Aortic stenosis

Mitral regurgitation

ECM remodeling

Download PDF