Share this page on LinkedIn
Share This Page on Google+
Share This Page on Twitter
tell someone about this page print this page
You are here: Contents > 2003 > Volume 12 Number 5 September 2003 > LEFT VENTRICULAR HYPERTROPHY > Role of Inadequate Adaptive Left Ventricular Hypertrophy in the Genesis of Mitral Regurgitation in Patients with Severe Aortic Stenosis: Implications for its Prevention

Role of Inadequate Adaptive Left Ventricular Hypertrophy in the Genesis of Mitral Regurgitation in Patients with Severe Aortic Stenosis: Implications for its Prevention

Sanjeev Palta MD, Kanwaljit S. Gill MD, Ramdas G. Pai MD
Loma Linda University and VA Medical Centers, Loma Linda, CA, USA

Background and aim of the study: Mitral regurgitation (MR) is frequent in patients with severe calcific aortic stenosis (AS). This complicates not only the clinical course of AS, but also its surgical management. The aim of the present study was to investigate the mechanism of genesis of MR in patients with severe AS.
Methods: The echocardiographic database was searched for subjects with severe AS defined as a calculated (continuity equation) aortic valve area <0.7 cm2. Patients with previous valve surgery were excluded; thus, the study group comprised 123 patients.
Results: Among 123 patients (mean age 75 ± 10 years) with severe AS, 54 (44%) had no MR, 37 (30%) had mild MR, 20 (16%) had moderate MR, and 12 (10%) had severe MR. Hence, moderate or severe MR was present in ~25% of patients. Patients with moderate or severe MR had a larger left ventricular (LV) end-diastolic diameter (5.1 ± 1.0 versus 4.8 ± 0.8 cm; p = 0.08), larger LV end-systolic diameter (3.8 ± 1.2 versus 3.1 ± 0.8 cm; p = 0.001), lower LV ejection fraction

(40 ± 16 versus 58 ± 18%; p = 0.0001), higher degree of aortic regurgitation (p = 0.002), larger left atrial diameter (4.7 ± 0.9 versus 4.1 ± 0.6 cm; p = 0.001), lower LV free wall thickness (1.1 ± 0.2 versus 1.3 ± 0.4 cm; p = 0.05), and lower combined wall thickness (2.4 ± 0.3 versus 2.7 ± 0.5 cm; p = 0.02) and relative wall thickness (0.5 ± 0.1 versus 0.6 ± 0.1 cm; p = 0.02). Both groups had similar degrees of AS and mitral annular calcification.
Conclusion: MR in severe AS is associated with a larger LV size and lesser wall thickness, and this may result from failure of adequate adaptive LV hypertrophy necessitated by the pressure overload imposed by AS. This might have important clinical implications in terms of timing of aortic valve replacement before the left ventricle begins to dilate, and also in the choice of pharmacologic therapy that may modulate the adaptive response of the left ventricle.

The Journal of Heart Valve Disease 2003;12:601-604
Role of Inadequate Adaptive Left Ventricular Hypertrophy in the Genesis of Mitral Regurgitation in Patients with Severe Aortic Stenosis: Implications for its Prevention

Click the above hyperlink to view the article, right click (Ctrl click on a Mac) to open in a new browser window or tab.

Purchase this Article

Please click the button below to purchase this article. Single article purchases are provided at $50.00 per article. Upon clicking the button below, single article user account subscription details are requested and, upon successful payment, a single article user account is created. Single articles are availble in your account for seven days after purchase.