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You are here: Contents > 2014 > Volume 23 Number 1 January 2014 > DEVICE EVALUATION > Long-Term Outcomes Following Medtronic Open Pivot™ Valved Conduit

Long-Term Outcomes Following Medtronic Open Pivot™ Valved Conduit

Rishendran Naidoo1, Bronwyn Pearse1, Peter J. Tesar1, Su-ann Yap1, Adrian G. Barnett2, Trevor Fayers1

1Department of Cardiothoracic Surgery, The Prince Charles Hospital, Brisbane, 2Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia

Background and aim of the study: Aortic root replacement is a complex procedure, though subsequent modifications of the original Bentall procedure have made surgery more reproducible. The study aim was to examine the outcomes of a modified Bentall procedure, using the Medtronic Open Pivot™ valved conduit. Whilst short-term data on the conduit and long-term data on the valve itself are available, little is known of the long-term results with the valved conduit.

Methods: Patients undergoing aortic root replacement between February 1999 and February 2010, using the Medtronic Open Pivot valved conduit were identified from the prospectively collected Cardiothoracic Register at The Prince Charles Hospital, Brisbane, Australia. All patients were followed up echocardiographically and clinically. The primary end-point was death, and a Cox proportional model was used to identify factors associated with survival. Secondary end-points were valve-related morbidity (as defined by STS guidelines) and postoperative morbidity. Predictors of morbidity were identified using logistic regression.

Results: A total of 246 patients (mean age 50 years) was included in the study. The overall mortality was 12%, with actuarial 10-year survival 79% and a 10-year estimate of valve-related death of 0.04 (95% CI: 0.004, 0.07). Preoperative myocardial infarction (p = 0.004, HR 4.74), urgency of operation (p = 0.038, HR 2.8) and 10% incremental decreases in ejection fraction (p = 0.046, HR 0.69) were predictive of mortality. Survival was also affected by the valve gradients, with a unit increase in peak gradient reducing mortality (p = 0.021, HR 0.93). Valve-related morbidity occurred in 11 patients. Urgent surgery (p <0.001, OR 4.12), aortic dissection (p = 0.015, OR 3.35), calcific aortic stenosis (p = 0.016, OR 2.35) and Marfan syndrome (p = 0.009, OR 3.75) were predictive of postoperative morbidity. The reoperation rate was 1.2%.

Conclusion: The Medtronic Open Pivot valved conduit is a safe and durable option for aortic root replacement, and is associated with low morbidity and 10-year survival of 79%. However, further studies are required to determine the effect of valve gradient on survival.

The Journal of Heart Valve Disease 2014;23:105-111

Long-Term Outcomes Following Medtronic Open Pivot™ Valved Conduit

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