Nehir Sucu, Lulufer Tamer, Barlas Aytacoglu, Ayse Polat, H. Ali Dondas, Ali Gul, Murat Dikmengil, Ugur Atik
Background and aim of the study: Although current bioprosthetic heart valves have low thrombogenicity and favorable hemodynamic properties, their durability remains unsatisfactory. Valve failure usually occurs from calcific degeneration. The study aim was to investigate the effect of a chelating agent, citric acid (CA), on calcification in bovine pericardium.
|further 3 days. To investigate calcification rate, pericardial patches were inserted into the dorsal pouches of 15 juvenile male Wistar rats for 42 days. Tissue calcium levels were measured with atomic absorption spectrophotometer, and also assessed histopathologically.
Results: The calcium content of CA-treated pericardium was significantly lower than that of controls (66.4 ± 33.5 and 111.4 ± 27.2 mg/g, respectively; p = 0.000). In general, the degree of calcification in histological sections agreed well with results of the chemical analyses. Control pericardial tissues showed moderate to severe solid mineral depositions, predominantly parallel to the implant surface, whereas only minor traces of calcium were found in CA-treated tissues.
Conclusion: These preliminary data suggest that calcific degeneration in bovine pericardium may be reduced by using CA as a chelating agent.
The Journal of Heart Valve Disease 2004;13:697-700
|Inhibition of Calcification with Citric Acid in Pericardial Bioprosthetic Heart Valve Material: A Preliminary Report|
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