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You are here: Contents > 2004 > Volume 13 Number 5 September 2004 > CASE REPORTS > Hutchinson-Gilford Progeria Syndrome with Severe Calcific Aortic Valve Stenosis and Calcific Mitral Valve

Hutchinson-Gilford Progeria Syndrome with Severe Calcific Aortic Valve Stenosis and Calcific Mitral Valve

Krishnakumar Nair, Padmakumar Ramachandran, Kavassery M. Krishnamoorthy, Santhosh Dora, Tharakan J. Achuthan
Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum, India

The case of a 12-year-old girl with clinical features of progeria with severe calcific valvar aortic stenosis is presented. The mitral valve showed the presence of calcium, and peripheral vascular disease was also present, though there was no family history of this. Aortic valve replacement was deferred because of insufficient data relating to this condition. The genetics and

phenotypic mechanisms of the disease are reviewed. In view of the association of progeria with valve disease, all patients should undergo electrocardiography and echocardiography as part of their routine work-up.
The Journal of Heart Valve Disease 2004;13:866-869

Hutchinson-Gilford Progeria Syndrome with Severe Calcific Aortic Valve Stenosis and Calcific Mitral Valve

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