Successful Treatment of Very Early Thrombosis of SAPIEN 3 Valve with Direct Oral Anticoagulant Therapy
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Neil Ruparelia, Vasileios F. Panoulas, Angela Frame, Nilesh Sutaria, Ben Ariff, Deepa Gopalan, Andrew Chukwuemeka, Ghada W. Mikhail, Iqbal S. Malik Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK |
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Thrombosis of transcatheter aortic valve implantation (TAVI) is an uncommon complication that commonly occurs weeks to months following the procedure. Herein are described the details of a patient who presented with a recurrence of symptoms days after intervention with a bioprosthesis thrombosis that was successfully treated with direct oral anticoagulant (DOAC) therapy and resulted in hemodynamic improvement and resolution of symptoms. Whilst a previous trial of DOAC therapy with mechanical valves was stopped due to elevated events in comparison to warfarin, a TAVI valve may be different, and the rapid onset of action and reduced bleeding risk may be beneficial in this patient group. |
Video 2: Two-dimensional transesophageal echocardiography (TEE) long-axis view of the aortic valve prosthesis with color Doppler, demonstrating restricted movement of the valve cusp and resultant turbulent flow. The Journal of Heart Valve Disease 2016;25:211-213 |
| Successful Treatment of Very Early Thrombosis of SAPIEN 3 Valve with Direct Oral Anticoagulant Therapy | |
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